<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramanujam, Nirmala</style></author><author><style face="normal" font="default" size="100%">Mitchell, M. F.</style></author><author><style face="normal" font="default" size="100%">Mahadevan, A.</style></author><author><style face="normal" font="default" size="100%">Thomsen, S.</style></author><author><style face="normal" font="default" size="100%">Silva, E.</style></author><author><style face="normal" font="default" size="100%">Richards-Kortum, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN)</style></title><secondary-title><style face="normal" font="default" size="100%">Gynecol Oncol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Spectrometry, Fluorescence/instrumentation</style></keyword><keyword><style  face="normal" font="default" size="100%">Algorithms</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical Intraepithelial Neoplasia/*diagnosis/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervix Uteri/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Colposcopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Diagnosis, Differential</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Fiber Optic Technology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Lasers</style></keyword><keyword><style  face="normal" font="default" size="100%">Optical Fibers</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyomavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Sensitivity and Specificity</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor Virus Infections/diagnosis/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterine Cervical Neoplasms/*diagnosis/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterine Cervicitis/diagnosis/pathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1994</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8307499</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><edition><style face="normal" font="default" size="100%">1994/01/01</style></edition><volume><style face="normal" font="default" size="100%">52</style></volume><pages><style face="normal" font="default" size="100%">31-8</style></pages><isbn><style face="normal" font="default" size="100%">0090-8258 (Print)0090-8258 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">A spectroscopic system incorporating a pulsed nitrogen laser, an optical fiber probe, and an optical multichannel analyzer was utilized to record fluorescence spectra of the intact cervix at colposcopy. Spectra were obtained from 66 colposcopically normal areas and 49 histologically abnormal areas (5 pathologic inflammation, 21 HPV infection, 9 CIN I, 10 CIN II, and 4 CIN III) in 28 patients. The resulting spectra could be used to differentiate histologically abnormal tissues from colposcopically normal tissues with a sensitivity, specificity, and positive predictive value of 92, 90, and 88%. Furthermore, CIN could be differentiated from nonneoplastic abnormal tissues with a sensitivity, specificity, and positive predictive value of 87, 73, and 74%. These results suggest that laser-induced fluorescence can be used in the recognition and differential diagnosis of CIN at colposcopy.</style></abstract><accession-num><style face="normal" font="default" size="100%">8307499</style></accession-num><notes><style face="normal" font="default" size="100%">Ramanujam, NMitchell, M FMahadevan, AThomsen, SSilva, ERichards-Kortum, RResearch Support, Non-U.S. Gov'tUnited statesGynecologic oncologyGynecol Oncol. 1994 Jan;52(1):31-8.</style></notes><auth-address><style face="normal" font="default" size="100%">Biomedical Engineering Program, University of Texas, Austin 78712.</style></auth-address></record></records></xml>