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Journal Articles
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2009
Lo JY, Yu B, Fu HL, Bender JE, Palmer GM, Kuech TF, Ramanujam N. A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes. Optics Express. 17 (3):1372-1384, 2009.
Chang VT, Cartwright PS, Bean SM, Palmer GM, Bentley RC, Ramanujam N. Quantitative physiology of the precancerous cervix in vivo via optical spectroscopy. Neoplasia. Accepted 2008.
2008
Brown JQ, Wilke LG, Geradts J, Kennedy SA, Palmer GM, Ramanujam N. "Quantitative optical spectroscopy: A robust tool for direct measurement of breast cancer oxygenation and total hemoglobin content in vivo," Cancer Research, Accepted, 2008.
Yu B, Lo JY, Palmer GM, Bender J, Kuech TF, Ramanujam N, “A Cost-Effective Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering In Vivo,” Journal of Biomedical Optics. 13 (6): 060505, 2008.
Zhu C, Burnside ES, Sisney GA, Salkowski LR, Harter JM, Yu B, Ramanujam N, Fluorescence Spectroscopy: an Adjunct Diagnostic Tool to Image Guided Core Needle Biopsy of the Breast, submitted to IEEE Transactions on Biomedical Engineering (2008).
Palmer, G.M., and N. Ramanujam. "Monte Carlo based model for the extraction of intrinsic fluorescence from turbid media." J Biomed Opt. 13(2): p. 024017-9, 2008.
- Zhu C, Palmer G, Breslin T, Harter J, Ramanujam N, “Diagnosis of Breast Cancer using Fluorescence and Diffuse Reflectance Spectroscopy: a Monte Carlo Model Based Approach”, J Biomed Opt, Vol. 13, No. 3, 2008, pp.034015.
- Yu B, Fu H, Bydlon T, Bender JE, and Ramanujam N, "Diffuse Reflectance Spectroscopy with a Self-Calibrating Fiber Optic Probe," Optics Letters. 33(16):1783-1785 (2008).
Lazebnik M, Zhu C, Palmer GM, Harter J, Sewall S, Ramanujam N, Hagness S, “Electromagnetic Spectroscopy of Normal Breast Tissue Specimens Obtained from Reduction Surgeries: Comparison of Optical and Microwave Properties”, accepted for publication on IEEE Transactions on Biomedical Engineering (2008).
Vishwanath K, Yuan H, Moore L, Dewhirst M, Ramanujam N. “Optical Spectroscopy: an In Vivo, Non-invasive and Quantitative Technique for Assessing Tumor Response to Treatments.” Cancer research (submitted).
-Bender JE, Vishwanath K, Moore LK, Brown JQ, Chang V, Palmer, GM, Ramanujam N. "A Robust Monte Carlo Model for the Extraction of Biological Absorption and Scattering in Vivo," IEEE TBME (accepted 2008).
-Zhu C, Breslin TM, Harter J, Ramanujam N, “Model Based and Empirical Spectral Analysis for the Diagnosis of Breast Cancer”, Optics Express 16(19): 14961-14978 (2008).
2007
Skala MC, Riching KM, Gendron-Fitzpatrick A, Eliceiri KW, and Ramanujam N. In vivo multiphoton microscopy of metabolic oxidation-reduction states and fluorescence lifetimes in normal and pre-cancerous epithelia. Proc Nat Acad Sci. 104(49): 19494-19499, 2007.
- Skala MC, Palmer GM, Vrotsos KM, Gendron-Fitzpatrick A, Ramanujam N. Comparison of a Monte Carlo based physical model and principal component analysis for the diagnosis of normal and neoplastic epithelial tissues in vivo using diffuse reflectance spectroscopy. Optics Express, (15):12; 7863-7875 (2007).
- Yu B, Burnside Rollins E, Sisney GA, Harter JM, Zhu C, Dhalla AH, and Ramanujam N, Feasibility of Near-Infrared Diffuse Optical Spectroscopy on Patients Undergoing Image-Guided Core-Needle Biopsy, Optics Express, 15(12): 7335-50, 2007.
- Liu Q, Ramanujam N, A Scaling Method for Fast Monte Carlo Simulation of Diffuse Reflectance Spectra from Multi-layered Turbid Media, Journal of the Optical Society of America, 24(4): 1011-1025, 2007.
- Skala MC, Riching KM, Bird DK, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, Keely PJ, Ramanujam N, In vivo Multiphoton Fluorescence Lifetime Imaging of Protein-bound and Free NADH in Normal and Pre-cancerous Epithelia, Journal of Biomedical Optics, 12(2): 024014, 2007.
- Palmer GM, and Ramanujam N, Use of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties, IEEE Transactions in Biomedical Engineering, 54(8): 1533-5, 2007.
2006
- Liu Q, Ramanujam N, Sequential Estimation of Optical Properties of A Two-Layered Epithelial Tissue Model from Depth-Resolved Ultraviolet-Visible Diffuse Reflectance Spectra, Applied Optics, 45(19): 4776-90, 2006.
- Zhu C, Palmer GM, Breslin T, Harter J, Ramanujam N, Diagnosis of Breast cancer using Diffuse Reflectance Spectroscopy: Comparison of a Monte Carlo vs. Partial Least Squares Analysis based Feature Extraction Technique, Lasers in Surgery and Medicine, 38: 714-724, 2006.
- Millon SR, Roldan-Perez KM, Riching KM, Palmer GM, Ramanujam N., Effect of optical clearing agents on the in vivo optical properties of squamous epithelial tissue, Lasers in Surgery and Medicine, 38(10): 92-7, 2006.
- Palmer GM, and Ramanujam N. A
Monte Carlo based inverse model for calculating tissue optical properties,
part I: Theory and validation on synthetic phantoms ,Appl Opt,
45(5): 1062-1071, 2006.
- Palmer GM, Zhu C, Breslin TM, Xu F, Gilchrist KW, and Ramanujam N.
A Monte
Carlo based inverse model for calculating tissue optical properties,
part II: Application to breast cancer diagnosis. ,Appl Opt, 45(5):1072-1078, 2006.
2005
- Zhu C, Palmer GM, Breslin TM, Xu F, Ramanujam N The
use of a multi-separation fiber optic probe for the optical diagnosis
of breast cancer, Journal of Biomedical Optics, 10(2): 24-32, 2005.
- Bird DK, Yan, L, Vrotsos KM, EliceiriKW, Vaughan EM, Keely PJ, WhiteJG,
Ramanujam N Metabolic
Mapping of MCF-10A Human Breast Cells via Multiphoton Fluorescence Lifetime
Imaging Microscopy (FLIM) of the Coenzyme NADH, Cancer Research,
65(19): 8766-8773, 2005.
- Skala MC, Squirrell JM, Vrotsos KM, Eickhoff JC, Gendron-Fitzpatrick A,
Eliceiri KW, and Ramanujam N, Multiphoton
Microscopy of Endogenous Fluorescence Differentiates Normal, Precancerous,
and Cancerous Squamous Epithelial Tissues, Cancer Research 2005,
65(4):1180-1186, 2005.
2004
- Lubawy C, Ramanujam N, Endoscopically
compatible near infrared photon migration probe, Optics Letters,
29(17): 2022-2024, 2004.
- Quan Liu, Nirmala Ramanujam, “
Experimental
proof of feasibility of using an angled fiber-optic probe for depth-sensitive
fluorescence spectroscopy of turbid media”, Optics
Letters, 29(17), 2004.
- Skala MC, Palmer GM, Zhu C, Liu Q, Vrotsos KM, Marshek-Stone CL,
Gendron-Fitzpatrick A, and Ramanujam N, Investigation
of Fiber-Optic Probe Designs for Optical Spectroscopic Diagnosis of
Epithelial Pre-Cancers, Lasers in Surgery and Medicine 34:25-38, 2004.
2003
- Liu Q, Zhu C, Ramanujam N, Experimental
validation of Monte Carlo modeling of fluorescence in tissues in the
UV-visible spectrum, Journal of Biomedical Optics, 8(2): 223-236,
2003.
- Zhu C, Liu Q, Ramanujam N, Effect
of fiber optic probe geometry on depth-resolved fluorescence measurements
from epithelial tissues: a Monte Carlo simulation, Journal of Biomedical
Optics, 8(2): 237-247, 2003.
- Gill EM, Malpica A, Alford RE, Nath AR, Follen M, Richards-Kortum
RR, Ramanujam N, Relationship
Between Collagen Autofluorescence of the Human Cervix and Menopausal
Status, Photochemistry and Photobiology, 77(6):653-658, 2003.
- Palmer, G.M., C. Zhu, T.M. Breslin, F. Xu, K.W. Gilchrist, and N.
Ramanujam, Comparison of
multiexcitation fluorescence and diffuse reflectance spectroscopy for
the diagnosis of breast cancer, IEEE Trans BME, 50(11): 1233-1242, 2003.
- R. Choe, T. Durduran, G. Yu, M. J. M. Nijland, B. Chance, A. G. Yodh,
and N. Ramanujam, Transabdominal
near infrared oximetry of hypoxic stress in fetal sheep brain in utero,
PNAS, 100(22): 12950-12954, 2003.
- Palmer G.M., Keely P.J., Breslin T.M., Ramanujam N.,
Autofluorescence
spectroscopy of normal and malignant human breast cell lines, Photochemistry
and Photobiology, 78(5): 462-469, 2003
- Breslin, T.M., F. Xu, G.M. Palmer, C. Zhu, K.W. Gilchrist, N. Ramanujam,
Autofluorescence and Diffuse Reflectance Properties
of Malignant and Benign Breast Tissues, Annals of Surgical Oncology,
11(1): 65-71, 2003.
2002
- Gu Y, Qian Z, Chen J, Blessington D, Ramanujam N, Chance B, High-resolution
three-dimensional scanning optical image system for intrinsic and extrinsic
contrast agents in tissue. Review of Scientific Instruments, 73(10):
172-178, 2002.
- Palmer GM, Marshek CL, Vrotsos KM, Ramanujam N, Optimal
methods for fluorescence and diffuse reflectance measurements of tissue
biopsy samples, Lasers in Surgery and Medicine, 3(3), 191-200, 2002.
- Quan L, Ramanujam N, Relationship
between depth of a target in a turbid medium and fluorescence measured
by a variable-aperature method, Optics Letters, 27(2), 104-107,
2002.
2001
- Ramanujam N, Chen J, Gossage K, Richards-Kortum R, Chance B, Fast
and non-invasive, fluorescence imaging of biological tissues, in vivo
using a flying spot scanner, IEEE Transactions in Biomedical Engineering,
48(9),1034-1041, 2001.
2000
- Ramanujam N, Vishnoi G, Hielscher AH, Rode ME, Forouzan I, Chance
B, Photon migration
through the fetal head in utero using continuous wave, near infrared
spectroscopy: clinical and experimental model studies, Journal of
Biomedical Optics, 5, 163-172, 2000.
- Vishnoi G, Hielscher AH, Ramanujam N, Chance B, Photon
migration through the fetal head in utero using continuous wave, near
infrared spectroscopy: development and evaluation of experimental and
numerical models, Journal of Biomedical Optics, 5, 173-184, 2000.
- Jacques SL, Ramanujam N, Vishnoi G, Choe R, Chance B,
Modeling
photon transport in transabdominal fetal oximetry, Journal of Biomedical
Optics, 5(3), 283-286, 2000.
- Zourabian A, Chance B, Ramanujam N, Martha Rode, David A. Boas,
Trans-abdominal
Monitoring of fetal arterial blood oxygenation using pulse oximetry,
Journal of Biomedical Optics, 5(4), 391-405, 2000.
- Ramanujam N, Richards-Kortum R, Thomsen S, Mahadevan-Jansen A, Follen
M, Chance B, Low temperature
fluorescence imaging of freeze-trapped human cervical tissues, Optics
Express, 8(6), 335-343, December 2000.
1999
Mitchell MF, Cantor S, Ramanujam N, Tortolero-Luna G, Richards-Kortum
RR, Fluorescence spectroscopy for the diagnosis of squamous intraepithelial
lesions of the cervix, Obstetrics and Gynecology, 93(3), 462-470, 1999.
- Yazdi Y, Ramanujam N, Lotan R, Kline K, Mitchell MF, Hittelman W,
Richards-Kortum RR, Resonance
Raman spectroscopy at 257 nm excitation of normal and malignant cultured
breast and cervical cells, Applied Spectroscopy, 53(1), 82-85, 1999.
Ramanujam N, Long H, Rode M, Morgan M, Forouzan I, Chance B, Ante-partum,
trans-abdominal near infrared spectroscopy: feasibility of measuring
photon migration through the fetal head in utero, Journal of Maternal
Fetal Medicine, 8, 275-288, 1999.
1998
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Tumer K, Ramanujam N, Ghosh J, Richards-Kortum RR,
Ensembles
of Radial Basis Function networks for spectroscopic screening of cervical
pre-cancer, IEEE Transactions on Biomedical Engineering, 45(8),
953-961, 1998.
- Ramanujam N, Du C, Ma HY, Chance B, Sources
of phase noise in homodyne and heterodyne phase modulation devices used
for tissue oximetry studies, Review of Scientific Instruments, 69(8),
3042-3054, 1998.
- Chance B, Cope M, Dugan B, Ramanujam N, Tromberg B, Phase
measurements of absorbers and scatterers in tissue; review, Review
of Scientific Instruments, 69(10), 3457-3481, 1998.
- Trujillo EV, Sandison DR, Utzinger U, Ramanujam N, Follen Mitchell
M, Richards-Kortum RR, Method
to determine tissue fluorescence efficiency in vivo and predict signal
to noise ratio for spectrometers, Applied Spectroscopy, 52(7), 943-951,
1998.
Mahadevan-Jansen A, Follen Mitchell M, Ramanujam N, Malpica A, Thomsen
S, Utzinger U, Richards-Kortum RR, Near-Infrared Raman spectroscopy
for in vitro detection of cervical precancers, Photochemistry and Photobiology,
68,123-132, 1998.
Mahadevan-Jansen A, Follen Mitchell M, Ramanujam N, Utzinger U, Richards-Kortum
R, Development of a fiber optic probe to measure NIR Raman spectra of
cervical tissue in vivo, Photochemistry and Photobiology, 68(3), 427-31,
1998.
1996
Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright
T, Atkinson A, Richards-Kortum RR, Development of a multivariate statistical
algorithm to analyze human cervical tissue fluorescence spectra acquired
in vivo, Lasers in Surgery and Medicine, 19(1), 46-62, 1996.
Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright
T, Atkinson A, Richards-Kortum RR, Spectroscopic diagnosis of Cervical
Intraepithelial Neoplasia (CIN) in vivo using laser-induced fluorescence
spectra at multiple excitation wavelengths, Lasers in Surgery and Medicine,
19(1), 63-72, 1996.
- Ramanujam N, Mitchell MF, Mahadevan-Jansen A, Thomsen S, Staerkel
G, Malpica A, Wright T, Atkinson A, Richards-Kortum RR, Cervical
pre-cancer detection using a multivariate statistical algorithm based
on laser induced fluorescence spectra at multiple excitation wavelengths,
Photochemistry and Photobiology, 64, 720-735, 1996.
1994
Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards-Kortum
RR, Fluorescence spectroscopy: a diagnostic tool for Cervical Intraepithelial
Neoplasia (CIN), Gynecologic Oncology, 52, 31-38, 1994.
- Ramanujam N, Mitchell MF, Mahadevan A, Warren S, Thomsen S, Richards-Kortum
RR, In Vivo diagnosis of
Cervical Intraepithelial Neoplasia (CIN) using 337 nm laser induced
fluorescence, Proc. Natl. Acad. Sci. USA, 91, 10193-10197, 1994.
Ramanujam .N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards-Kortum
RR, Fluorescence spectroscopy of the cervix, Consultations in Obstetrics
and Gynecology, 6(1), 62-69, 1994.
Durkin AJ, Jaikumar S, Ramanujam N, Richards-Kortum RR, Relation between
fluorescence spectra of dilute and turbid samples, Applied Optics, 33(3),
414-423, 1994.
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