Book Chapters and Review Articles
Brown, Q. J., T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, et al., "Optical Assessment of Tumor Resection Margins in the Breast", IEEE Journal of Selected Topics in Quantum Electronics, vol. 16, issue 3, pp. 530 - 544, 05/2010.
Archived Journal Articles
Lazarides, A., M. Whitley, D. Strasfeld, D. Cardona, J. Ferrer, J. Mueller, H. Fu, B. S. DeWitt, B. Brigman, N. Ramanujam, et al., "A fluorescence-guided laser ablation system for removal of residual cancer in a mouse model of soft tissue sarcoma", Theranostics, vol. 6, issue 2, pp. 155-166, 2016.
Nichols, B. S., C. E. Schindler, J. Q. Brown, L. G. Wilke, C. S. Mulvey, M. S. Krieger, J. Gallagher, J. Geradts, R. Greenup, K. von Windheim, et al., "A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins", PloS ONE, 06/2015.
Hu, F., K. Vishwanath, W. H. Beumer, L. Puscas, H. R. Afshari, R. M. Esclamado, R. Scher, S. Fisher, J. Lo, C. Mulvey, et al., "Assessment of the sensitivity and specificity of tissue-specific-based and anatomical-based optical biomarkers for rapid detection of human head and neck squamous cell carcinoma", Oral Oncology, vol. 50, issue 9, pp. 848-56, 09/2014.
Barrott, J. J., P. F. Hughes, T. Osada, X. Y. Yang, Z. C. Hartman, D. R. Loiselle, N. Spector, L. Neckers, N. Rajaram, F. Hu, et al., "Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells", Chemistry and Biology, 09/2013.
Liu, C., N. Rajaram, K. Vishwanath, T. Jiang, G. M. Palmer, and N. Ramanujam, "Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model", Journal of Biomedical Optics, vol. 17, issue 7, pp. 077012, 2012.
Bydlon, T. M., W. T. Barry, S. A. Kennedy, Q. J. Brown, J. E. Gallagher, L. G. Wilke, J. Geradts, and N. Ramanujam, "Advancing Optical Imaging for Breast Margin Assessment: An Analysis of Excisional Time, Cautery, and Patent Blue Dye on Underlying Sources of Contrast", PLoS ONE, vol. 7, issue 12, pp. e51418, 12/2012.
Millon, S. R., J. H. Ostrander, S. Yazdanfar, Q. J. Brown, J. E. Bender, A. Rajeha, and N. Ramanujam, "Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes", Journal of Biomedical Optics, vol. 15, issue 1, pp. 018002, 2010.
Bydlon, T. M., S. A. Kennedy, L. M. Richards, Q. J. Brown, B. Yu, M. K. Junker, J. Gallagher, J. Geradts, L. G. Wilke, and N. Ramanujam, "Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins", Optics Express, vol. 18, issue 8, pp. 8058, 2010.
Gill, E. M., J. A. Straseski, C. A. Rasmussen, S. J. Liliensiek, K. W. Eliceiri, N. Ramanujam, J. G. White, and L. B. Allen-Hoffmann, "Visualization of Morphological and Molecular Features Associated with Chronic Ischemia in Bioengineered Human Skin", Microscopy and Microanalysis, vol. 16, issue 02, pp. 117, 4/2010.
Brown, J. Q., L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, "Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo", Cancer Research, vol. 69, issue 7, pp. 2919 - 2926, 03/2009.
Wilke, L. G., Q. J. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, "Rapid noninvasive optical imaging of tissue composition in breast tumor margins", The American Journal of Surgery, vol. 198, issue 4, pp. 566 - 574, 10/2009.
Lazebnik, M., C. Zhu, G. M. Palmer, J. Harter, S. Sewall, N. Ramanujam, and S. C. Hagness, "Electromagnetic spectroscopy of normal breast tissue specimens obtained from reduction surgeries: comparison of optical and microwave properties", IEEE Trans Biomed Eng, 2008/10/08, vol. 55, no. 10, pp. 2444-51, Oct, 2008.
Skala, M. C., K. M. Riching, A. Gendron-Fitzpatrick, J. Eickhoff, K. W. Eliceiri, J. G. White, and N. Ramanujam, "In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia", Proc Natl Acad Sci U S A, 2007/11/29, vol. 104, no. 49, pp. 19494-9, Dec 4, 2007.
Skala, M. C., K. M. Riching, D. K. Bird, A. Gendron-Fitzpatrick, J. Eickhoff, K. W. Eliceiri, P. J. Keely, and N. Ramanujam, "In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia", J Biomed Opt, 2007/05/05, vol. 12, no. 2, pp. 024014, Mar-Apr, 2007.
Skala, M. C., G. M. Palmer, K. M. Vrotsos, A. Gendron-Fitzpatrick, and N. Ramanujam, "Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy", Opt Express, 2007/10/04, vol. 15, no. 12, pp. 7863-75, Jun 11, 2007.
Palmer, G. M., and N. Ramanujam, "Use of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties", IEEE Trans Biomed Eng, 2007/08/19, vol. 54, no. 8, pp. 1533-5, Aug, 2007.
Liu, Q., and N. Ramanujam, "Scaling method for fast Monte Carlo simulation of diffuse reflectance spectra from multilayered turbid media", J Opt Soc Am A Opt Image Sci Vis, 2007/03/16, vol. 24, no. 4, pp. 1011-25, Apr, 2007.
Liu, Q., and N. Ramanujam, "Sequential estimation of optical properties of a two-layered epithelial tissue model from depth-resolved ultraviolet-visible diffuse reflectance spectra", Appl Opt, 2006/06/27, vol. 45, no. 19, pp. 4776-90, Jul 1, 2006.
Zhu, C., G. M. Palmer, T. M. Breslin, J. Harter, and N. Ramanujam, "Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique", Lasers in Surgery and Medicine, vol. 38, no. 7: Wiley Subscription Services, Inc., A Wiley Company, pp. 714–724, 2006.
Palmer, G. M., and N. Ramanujam, "Monte Carlo-based inverse model for calculating tissue optical properties. Part I: Theory and validation on synthetic phantoms", Appl Opt, 2006/03/04, vol. 45, no. 5, pp. 1062-71, Feb 10, 2006.
Skala, M. C., J. M. Squirrell, K. M. Vrotsos, J. C. Eickhoff, A. Gendron-Fitzpatrick, K. W. Eliceiri, and N. Ramanujam, "Multiphoton microscopy of endogenous fluorescence differentiates normal, precancerous, and cancerous squamous epithelial tissues", Cancer Res, 2005/03/01, vol. 65, no. 4, pp. 1180-6, Feb 15, 2005.
Liu, Q., and N. Ramanujam, "Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media", Opt Lett, 2004/10/01, vol. 29, no. 17, pp. 2034-6, Sep 1, 2004.
Zhu, C., Q. Liu, and N. Ramanujam, "Effect of fiber optic probe geometry on depth-resolved fluorescence measurements from epithelial tissues: a Monte Carlo simulation", J Biomed Opt, 2003/04/10, vol. 8, no. 2, pp. 237-47, Apr, 2003.
Liu, Q., C. Zhu, and N. Ramanujam, "Experimental validation of Monte Carlo modeling of fluorescence in tissues in the UV-visible spectrum", J Biomed Opt, 2003/04/10, vol. 8, no. 2, pp. 223-36, Apr, 2003.
Quan, L., and N. Ramanujam, "Relationship between depth of a target in a turbid medium and fluorescence measured by a variable-aperture method", Opt Lett, 2007/11/17, vol. 27, no. 2, pp. 104-6, Jan 15, 2002.
Ramanujam, N., M. F. Mitchell, A. Mahadevan-Jansen, S. L. Thomsen, G. Staerkel, A. Malpica, T. Wright, N. Atkinson, and R. Richards-Kortum, "Cervical precancer detection using a multivariate statistical algorithm based on laser-induced fluorescence spectra at multiple excitation wavelengths", Photochem Photobiol, 1996/10/01, vol. 64, no. 4, pp. 720-35, Oct, 1996.
Ramanujam, N., M. F. Mitchell, A. Mahadevan, S. Thomsen, A. Malpica, T. Wright, N. Atkinson, and R. Richards-Kortum, "Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo", Lasers Surg Med, 1996/01/01, vol. 19, no. 1, pp. 46-62, 1996.
Ramanujam, N., M. F. Mitchell, A. Mahadevan, S. Thomsen, A. Malpica, T. Wright, N. Atkinson, and R. Richards-Kortum, "Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser-induced fluorescence spectra at multiple excitation wavelengths", Lasers Surg Med, 1996/01/01, vol. 19, no. 1, pp. 63-74, 1996.
Fu, H. L., N. Ramanujam, and J. Q. Brown, "Design and development of a wide-field structured illumination fluorescence imaging system for breast tumor margin assessment", SPIE, Photonics West – BIOS, San Francisco, CA, 2012.
Lo, J. Y., B. Yu, T. F. Kuech, and N. Ramanujam, "A compact, cost-effective diffuse reflectance spectroscopic imaging system for quantitative tissue absorption and scattering", Advanced Biomedical and Clinical Diagnostic Systems IX, San Francisco, California, USA, Proceedings of SPIE, pp. 78900B - 78900B-6, 2011.
Brown, Q. J., T. M. Bydlon, S. A. Kennedy, J. Geradts, L. G. Wilke, W. Barry, L. M. Richards, M. K. Junker, J. Gallagher, and N. Ramanujam, "Assessment of breast tumor margins via quantitative diffuse reflectance imaging", Biomedical Applications of Light Scattering IV, San Francisco, California, USA, Proceedings of SPIE, pp. 75730O - 75730O-7, 2010.
Brown, J. Q., B. Yu, and N. Ramanujam, "Tissue-mimicking phantoms for system calibration and validation in Quantitative Diffuse Reflectance Spectroscopy (Q-DRS)", Design and Performance Validation of Phantoms used in Conjunction with Optical Measurement of Tissue III, SPIE Photonics West – BIOS, San Francisco, CA, 2010.
Ramanujam, N., J. Q. Brown, T. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, L. G. Wilke, and J. Geradts, "Quantitative spectral reflectance imaging device for intraoperative breast tumor marin assessment", IEEE, Engineering in Medicine and Biology Society, 2009.