|Title||Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe|
|Publication Type||Peer Reviewed Archived Journal Publications|
|Year of Publication||2008|
|Authors||Yu, B, Fu, H, Bydlon, T, Bender, JE, Ramanujam, N|
|Date Published||Aug 15|
|ISBN Number||0146-9592 (Print)0146-9592 (Linking)|
|Keywords||*Optics and Photonics, Calibration, Equipment Design, Fiber Optic Technology/*instrumentation/*methods, Monte Carlo Method, Optical Fibers, Phantoms, Imaging, Reproducibility of Results, Spectrum Analysis/*instrumentation/*methods, Ultraviolet Rays|
Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/-7.2% and 3.5%+/-1.5%, respectively.