|Title||Rapid noninvasive optical imaging of tissue composition in breast tumor margins|
|Publication Type||Peer Reviewed Archived Journal Publications|
|Year of Publication||2009|
|Authors||Wilke, LG, Brown, QJ, Bydlon, TM, Kennedy, SA, Richards, LM, Junker, MK, Gallagher, J, Barry, WT, Geradts, J, Ramanujam, N|
|Journal||The American Journal of Surgery|
|Pagination||566 - 574|
BACKGROUND: In women undergoing breast conserving surgery (BCS), up to 60% can require re-excision. Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors.
METHODS: A prospective study of optical imaging of BCS margins is being performed. Optical images are transformed into tissue composition maps with parameters of total hemoglobin concentration, b-carotene concentration and scattering. The predicted outcome is then compared to the margin-level pathology.
RESULTS: Fifty-five margins from 48 patients have undergone assessment. Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002). These differences were notable in both in-situ and invasive disease.
CONCLUSIONS: We present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins.
|Short Title||The American Journal of Surgery|