A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes

TitleA strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes
Publication TypePeer Reviewed Archived Journal Publications
Year of Publication2009
AuthorsLo, JY, Yu, B, Fu, HL, Bender, JE, Palmer, GM, Kuech, TF, Ramanujam, N
JournalOpt Express
Volume17
Pagination1372-84
Date PublishedFeb 2
ISBN Number1094-4087 (Electronic)1094-4087 (Linking)
Accession Number19188966
Keywords*Light, *Phantoms, Imaging, *Scattering, Radiation, Absorption/radiation effects, Computer Simulation, Hemoglobins/metabolism, Humans, Monte Carlo Method, Optics and Photonics/*instrumentation, Spectrum Analysis/*methods
Abstract

A diffuse reflectance spectroscopy system was modified as a step towards miniaturization and spectral imaging of tissue absorption and scattering. The modified system uses a tunable source and an optical fiber for illumination and a photodiode in contact with tissue for detection. Compared to the previous system, it is smaller, less costly, and has comparable performance in extracting optical properties in tissue phantoms. Wavelength reduction simulations show the feasibility of replacing the source with LEDs to further decrease system size and cost. Simulated crosstalk analysis indicates that this evolving system can be multiplexed for spectral imaging in the future.

URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19188966
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