Use of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties

TitleUse of genetic algorithms to optimize fiber optic probe design for the extraction of tissue optical properties
Publication TypePeer Reviewed Archived Journal Publications
Year of Publication2007
AuthorsPalmer, GM, Ramanujam, N
JournalIEEE Trans Biomed Eng
Volume54
Pagination1533-5
Date PublishedAug
ISBN Number0018-9294 (Print)0018-9294 (Linking)
Accession Number17694876
Keywords*Algorithms, *Computer-Aided Design, Connective Tissue/*physiology, Equipment Design, Equipment Failure Analysis, Fiber Optic Technology/*instrumentation, Light, Optical Fibers, Photometry/*instrumentation/methods, Radiometry/*instrumentation/methods, Reproducibility of Results, Scattering, Radiation, Sensitivity and Specificity
Abstract

This paper outlines a framework by which the optimal illumination/collection geometry can be identified for a particular biomedical application. In this paper, this framework was used to identify the optimal probe geometry for the accurate determination of tissue optical properties representative of that in the ultraviolet-visible (UV-VIS) spectral range. An optimal probe geometry was identified which consisted of a single illumination and two collection fibers, one of which is insensitive to changes in scattering properties, and the other is insensitive to changes in the attenuation coefficient. Using this probe geometry in conjunction with a neural network algorithm, the optical properties could be extracted with root-mean-square errors of 0.30 cm(-1) for the reduced scattering coefficient (tested range of 3-40 cm(-1)), and 0.41 cm(-1) for the absorption coefficient (tested range of 0-80 cm(-1)).

URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17694876
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